![]() ![]() The work is made available under the Creative Commons CC0 public domain dedication.ĭata Availability: All code and data generated as part of this study are publicly available at. ![]() ![]() This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: JAccepted: JanuPublished: February 11, 2020 Del Valle, Los Alamos National Laboratory, UNITED STATES (2020) Combining genomics and epidemiology to track mumps virus transmission in the United States. Viral genomic data allowed us to reconstruct mumps transmission links not evident from epidemiological data or standard single-gene surveillance efforts and also revealed connections between apparently unrelated mumps outbreaks.Ĭitation: Wohl S, Metsky HC, Schaffner SF, Piantadosi A, Burns M, Lewnard JA, et al. Widespread transmission was surprising given high vaccination rates, but we found no genetic evidence that variants arising during this outbreak contributed to vaccine escape. Despite the presence of these multiple mumps virus lineages, the genomic data show that one lineage has dominated in the US since at least 2006. Our analysis suggests continuous, undetected circulation of mumps locally and nationally, including multiple independent introductions into Massachusetts and into individual communities. ![]() We paired epidemiological data from public health investigations with analysis of mumps virus whole genome sequences from 201 infected individuals, focusing on Massachusetts university communities. Unusually large outbreaks of mumps across the United States in 20 raised questions about the extent of mumps circulation and the relationship between these and prior outbreaks. ![]()
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